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U. Amstutz

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Open access Aug 2026

Resolving the complex CES1 genomic locus with Cas9-directed targeted long-read sequencing

Carboxylesterase 1 (CES1) is a major hepatic enzyme involved in the metabolism of many ester-containing drugs and endogenous lipids. However, genomic analysis of the CES1 locus is challenging due to highly homologous regions that confound short-read sequencing. To overcome these limitations, we applied an optimiz...

E. Lekka, A. Ambrodji, A. Nater et al. · 0 citations

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