Open access
Oct 2026
PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12
Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to generate isoform-specific inhibition for therapeut...
O. Vadas, S. Tiede, Maria Chaouki et al.
· Nature Communications · 1 citation