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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

U. Grewal

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5 papers indexed here

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Open access Aug 2026

RAF/MEK clamp inhibition with avutometinib and cetuximab in RAF1 S257L–mutated, anti-EGFR–refractory metastatic colorectal cancer in Gaucher’s disease

Abstract RAF1 alterations are rare in metastatic colorectal cancer (mCRC), occurring in roughly 0.5% of cases, and lack established treatment guidance. We present a patient with RAF1 S257L–mutated, RAS wild-type mCRC and concurrent type 1 Gaucher disease, whose baseline cytopenias precluded standard chemotherapy and cl...

A. Rose, Alix Rosenberg, U. Grewal et al. · 0 citations
Open access Sep 2026

Care delivery among patients with early-onset versus average-onset cholangiocarcinoma: a nationwide retrospective analysis

Background Cholangiocarcinoma (CCA) is an aggressive biliary malignancy with increasing incidence and poor prognosis. Although traditionally considered a disease of older adults, early-onset CCA (EOCCA; age <50 years) may represent a clinically distinct subgroup. Data evaluating diagnostic and treatment trajectories in...

U. Grewal, A. Nottke, B. Loeffler et al. · 0 citations
Sep 2026

Abstract A028: Metastatic potential defines an orthogonal axis of transcriptomic heterogeneity that predicts chemotherapy response and tumor microenvironment architecture in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) has traditionally been classified into two overarching transcriptomic subtypes—classical and basal—which have been associated with distinct clinical behaviors and therapeutic responses. We recently identified a previously unrecognized transcriptomic axis governing metastati...

Raymond E. Preston, Hong-Yun Huang, Margaret A. Hall et al. · 0 citations
Sep 2026

Comparative Analysis of Characteristics and Outcomes of Patients with Early-Onset Versus Average-Onset Small Bowel Neuroendocrine Tumors.

OBJECTIVES The incidence of early-onset gastrointestinal malignancies is increasing globally; however, early-onset small bowel neuroendocrine tumors (EO-SBNETs) remain poorly characterized. We evaluated clinical characteristics, treatment patterns, incidence trends, and survival outcomes of EO-SBNETs compared with aver...

Matthew T. Gao, Rishi R. Patel, Jason Semprini et al. · 0 citations
Open access Aug 2026

Age-stratified mutation patterns in early-onset colorectal cancer reveal distinct molecular features and therapeutic implications

Background Colorectal cancer (CRC) is increasingly diagnosed in younger adults, with evidence that early-onset cases (age <50 years) differ in the spectrum of prevalent gene mutations compared with older individuals. To evaluate how these age-related differences may inform testing guidelines and therapeutic development...

L. Liu, A. Rose, A. Samaddar et al. · 0 citations

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