Author

U. Kalinke

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Open access Aug 2026

Immune Cell-Specific SMN Expression and Sustained Immune Alterations in Treated Spinal Muscular Atrophy.

Mutations in the survival of motor neuron 1 (SMN1) can reduce functional SMN protein levels, which causes Spinal Muscular Atrophy (SMA), a disease affecting the nervous system and peripheral tissues, including the immune system. Yet, SMN expression across immune cell subsets and the impact of SMN-modulating therapies o...

I. Tapken, Katharina Rahmel-Stein, Christine Ehlers et al. · Journal of Clinical Investig... · 0 citations

Open access Jul 2026

JN.1-adapted vaccination is associated with readjustment of ancestral memory B cells toward neutralization within the JN.1 antigenic space

It is proposed that there is somatic hypermutation of existing B cell clones rather than de novo generation from naive B cells in JN.1-adapted booster vaccines and this finding indicates maturation of pre-existing, class-switched MBC rather than substantial de novo recruitment of naïve B cells.

M. Stankov, Matthias Bruhn, M. Hoffmann et al. · Nature Communications · 0 citations