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Open access Oct 2026

Genomic alterations and treatment define spatiotemporal patterns of glioblastoma recurrence.

The surgical margin is the primary site of glioblastoma recurrence, yet its molecular features remain poorly characterized. We performed histology-guided sampling and single-cell spatial transcriptomics of surgical margin and adjacent recurrent tumor regions, with matched primary tumors from 40 patients. The surgical m...

S. Artzi, D. Harwood, A. Locallo et al. · 0 citations
Open access Aug 2026

Genetic architecture of cytokine autoantibodies and associated risk of common diseases

Anti-cytokine autoantibodies are increasingly recognized as modulators of immune function and determinants of disease risk, yet their genetic basis and population-level impact remain unclear. Here we perform genome-wide association studies of autoantibodies against IL-1α, IL-6, IL-10, IFN-α, IFN-β, IFN-γ and GM-CSF in...

J. V. von Stemann, Joseph Dowsett, R. Teglgaard et al. · 0 citations

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