Author

U. Srivastava

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Feb 2026

Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease

It is demonstrated that pTau triggers phenotypes reflective of LC-NE hyperactivity in the early stages of AD pathogenesis, laying the foundation for the development of LC-based disease-modifying therapies to address neuropsychiatric manifestations.

Anuradha Korukonda, Harris E. Blankenship, K. Kam et al. · bioRxiv · 3 citations

Open access Jul 2026

Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells

It is shown that CRC cells transiently adopt a wound-healing program normally used by epidermal keratinocytes during tissue repair to enable metastatic dissemination, and this state is reversible, as cells reacquire primary tumor–like characteristics upon colonization of distant organs.

M. Sakahara, Takuya Okamoto, Kohei Kumegawa et al. · Nature Communications · 0 citations