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Author

U. Topal

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Open access Sep 2026

Component-Level Prognostic Evaluation of Clinical, Inflammatory, and Renal-Protein Markers for 30-Day Mortality in Older Patients with Perforated Peptic Ulcer

Objective: To compare clinical and laboratory markers for 30-day mortality in older patients with perforated peptic ulcer and assess biochemical markers beyond age and American Society of Anesthesiologists (ASA) class. Methods: Patients aged ≥65 years undergoing emergency surgery for perforated peptic ulcer from Januar...

O. Yalav, S. Gumus, Burak Aydoğan et al. · 0 citations
Open access Aug 2026

Claudin 18.2 Expression in Cholangiocarcinoma: Clinicopathological Heterogeneity, Prognostic Significance, and Impact of Positivity Thresholds

The relatively high expression observed in perihilar CCA, and large-duct intrahepatic CCA, and the independent prognostic significance identified at the 10% cutoff support the potential role of CLDN18.2 as a prognostic biomarker and therapeutic target in selected patients with CCA.

T. Toyran, Kivilcim Eren Ates, F. Pi̇şki̇n et al. · 0 citations
Open access Oct 2026

Comprehensive Complication Index Versus Clavien–Dindo Classification After CRS-HIPEC for Colorectal Peritoneal Metastases: Associations with 30- and 90-Day Readmission

Background and Objectives: To compare the Comprehensive Complication Index (CCI) with the conventional Clavien–Dindo (CD) classification for association with readmission after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for colorectal peritoneal metastases. Materials and Methods: Si...

U. Topal, Ibrahim Cogal, Yunus Kaycı et al. · 0 citations
Open access Sep 2026

Association of p16 Loss and EZH2 Overexpression with Clinicopathological Characteristics and Prognosis in Gastrointestinal Stromal Tumors

AbstractAim: Gastrointestinal stromal tumors (GISTs) exhibit marked heterogeneous clinical behavior that is not fully captured by conventional risk classification systems. This study aimed to evaluate the prognostic significance of loss of p16 expression and EZH2 overexpression and their relationship with clinicopathol...

T. Toyran, K. Ates, T. Köşeci et al. · 0 citations

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