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U. Vaishampayan

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Open access Sep 2026

10 Outcomes of Patients with Renal Cell Carcinoma Achieving Pathologic Complete or Major Response After Consolidative Nephrectomy Following Immune Checkpoint Inhibitor Therapy

Abstract Background Select patients with locally advanced or metastatic renal cell carcinoma (RCC) are candidates for consolidative nephrectomy (CN) following immune checkpoint blockade (ICB). Existing cohorts have been limited by heterogeneous pathological assessment and small sample sizes, limiting validation of path...

Paulo Siqueira Do Amaral, R. Mehra, J. Gordetsky et al. · 0 citations
Open access Sep 2026

16 ABBV-CLS-484: A Novel Oral PTPN2/1 Inhibitor for Cancer Immunotherapy

ABBV-CLS-484 is tolerable, with preliminary evidence of clinical activity in dose escalation, and additional strategies that combine ABBV-CLS-484 with VEGF TKIs, CAR-T therapy, and T cell engagers are being tested in preclinical models.

H. Hammers, E. Calvo, B. Carneiro et al. · 0 citations

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