Ulf-peter Apfel

A histidine-mediated, pendulum-like proton transport mechanism is required for the high catalytic activity of [FeFe]-hydrogenases

[FeFe]-hydrogenases are molecular hydrogen (H2) converting enzymes that employ a hexanuclear iron-complex, the H-cluster, as catalytic cofactor, and a proton transfer pathway (PTP) that allows efficient proton coupled electron transfer (PCET). Recent phylogenetic analyses revealed different groups of [FeFe]-hydrogenase...