Author

Ulrich Rothbauer

3 papers indexed here

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Open access Oct 2026

NanoBlocks: Creating Genetically Encoded Protein Switches Using Competitive Binding

Many regulatory mechanisms function by changing a molecule’s conformation such that it is switched between active and inactive states. Engineering macromolecules such as proteins to show robust conformational changes in response to arbitrary, well-defined molecular stimuli is of great interest in fields such as synth...

Silke Denis, V. V. Van Deuren, D. I. Frecot et al. · ACS Nano · 0 citations

Review Open access Oct 2026

Going viral - Virus-targeting nanobodies for research, diagnostics and therapy.

The increasing prevalence of viral diseases represents a major threat to global human health, highlighting the urgent need for advanced tools to study viral infections, improve diagnostics, and develop effective antiviral therapies. Antibodies are central to the immune response against viruses and are widely used in re...

D. Ebert, Ulrich Rothbauer · FEBS Letters · 0 citations

Open access Oct 2026

Single-domain antibody-conjugated lipid nanoparticles for selective mRNA delivery to CD4⁺ T cells and Brec1-mediated excision of HIV-1 proviral DNA

Approaches to curing HIV infection aim to eliminate the latent viral reservoir — long-lived, resting CD4⁺ T cells harboring integrated but transcriptionally silent proviral DNA — which persists despite effective antiretroviral therapy. The HIV-1 LTR-specific designer-recombinase Brec1 can precisely excise integrated pr...

Melanie Wittner, P. Hartjen, Oliver Keil et al. · Scientific Reports · 0 citations