BACKGROUND
Respiratory syncytial virus (RSV) causes acute respiratory illness in young children. The live-attenuated RSV vaccine candidate RSV/ΔNS2/Δ1313/I1314L (RSVt) has shown promising immunogenicity and safety in children aged 6-18 months. However, how baseline RSV serostatus influences immunogenicity and viral she...
O. Idoko, Sergio L. Vargas, Agustin Bueso et al.· The Lancet Microbe· 0 citations
ABSTRACT Intranasal COVID-19 vaccines with the ability to induce broad and durable mucosal and systemic immunity would be useful as stand-alone vaccines or in combination with injectable vaccines. We evaluated in hamsters the breadth of immunity and durability of protection elicited by co-administration of two live-att...
Hong-Su Park, Yumiko Matsuoka, Celia Santos et al.· Journal of Virology· 0 citations
In the hamster model, intranasal immunization with live-attenuated B/HPIV3 expressing SARS-CoV-2 S can provide durable protection for several months, and combining two antigenically distinct B/HPIV3 S-expressing vectors substantially broadens the antibody response.
Hong-Su Park, Yumiko Matsuoka, Celia Santos et al.· bioRxiv· 0 citations
ABSTRACT Intranasal COVID-19 vaccines with the ability to induce broad and durable mucosal and systemic immunity would be useful as stand-alone vaccines or in combination with injectable vaccines. We evaluated in hamsters the breadth of immunity and durability of protection elicited by co-administration of two live-att...
Hong-Su Park, Yumiko Matsuoka, Celia Santos et al.· Journal of Virology· 0 citations
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