Inorganic polyphosphate (polyP) is an ancient polymer conserved across all life, serving cell type- and location–specific functions in every major compartment. Yet its role at the plasma membrane, where it accumulates to peak levels in many primary cells, is largely unknown. Here we identify polyP as a stabilizing comp...
Inorganic polyphosphate (polyP) is a ubiquitous, multifunctional biomolecule that supports stress survival in bacteria. During nitrogen (N) starvation, Escherichia coli rapidly accumulates polyP, which drives the formation of RNA–protein granules that sustain long-term survival. What triggers this upregulation has rema...
It is demonstrated here that the interaction between H-NS and StpA fine-tunes the physico-chemical properties of nucleoid-associated compartments, thereby preserving gene repression and optimizing bacterial growth under stress.
Jian Guan, Bikash R. Sahoo, Tyler S. Brant et al.· Molecules and Cells· 0 citations
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