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Author

Urszula Orzeł

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2 papers indexed here

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Review Open access Sep 2026

ACE2 dysregulation and lipid metabolism: Mechanistic interplay between COVID-19 and neurodegeneration.

This review explored the intersection of ACE2 and lipid-related alterations in patients with Long COVID and their potential contribution to the progression of neurodegenerative diseases, and reviewed therapeutic strategies targeting ACE2.

Urszula Orzeł, Emilia Wójcik, Sławomir Filipek et al. · 0 citations
Open access Aug 2026

Cholesterol-Enriched Membranes Reshape the Conformational Ensemble and Interfacial Mechanics of ACE2.

Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane protein that functions as the primary entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 comprises a zinc-dependent extracellular domain (ECD) and forms homodimers, as resolved by cryoelectron microscopy (cryo-EM). Exper...

Urszula Orzeł, Sławomir Filipek, I. Moreira · 0 citations

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