The hybrid 4k exhibited maximum inhibition of α-glucosidase enzyme with favorable binding interactions, suggesting this framework is a potential lead motif for future antidiabetic drug discovery.
Anshul Grover, V. Asati, Jayant Sindhu et al.· Future Medicinal Chemistry· 0 citations
The structure–activity relationship (SAR) and cytotoxic activity of several quinazoline derivatives with demonstrated EGFR‐inhibitory antiproliferative activity and the EGFR‐mediated anticancer potential of quinazoline derivatives discovered after 2020 are reported.
Ankur Vaidya, Shweta Jain, B. Kumar et al.· ChemistrySelect· 0 citations
The hybrid AT5 may be used as potential lead compound after necessary structural modifications after necessaryStructural modifications in adamantane-appended 1,2,3-triazole hybrid conjugates.
Aman Ragshaniya, V. Asati, Jayant Sindhu et al.· Future Medicinal Chemistry· 1 citation
This review focuses on the AI-based approaches for target discovery, virtual screening, molecular generation, lead optimization, retro-synthesis, and structural modeling while also addressing issues of dataset bias, reproducibility, and real-world applicability.
