ABSTRACT Adaptive laboratory evolution (ALE) is a powerful strategy for exploring functional solution spaces, yet its pace is fundamentally constrained by low spontaneous mutation rates. Here, we present a broadly applicable genetic device that accelerates genome diversification in Gram‐negative bacteria through the tr...
T. Aparicio, Gabriele Capriglia, F. Mapelli et al.· Microbial Biotechnology· 0 citations
This Perspective examines the trajectory of Spain's synthetic biology community, highlighting foundational contributions, current strengths and emerging opportunities, and the need to balance engineering ambition with biological complexity, innovation with deployability and control with emergence.
Germán Rivas, Irene Otero-Muras, V. de Lorenzo· Engineering Biology· 0 citations
ABSTRACT The deliberate release of genetically engineered microorganisms for environmental applications has remained largely blocked since the early days of recombinant DNA technology, when limited ecological knowledge, lack of success stories and public apprehension shaped a culture of caution and restrictive regulati...
V. de Lorenzo· Microbial Biotechnology· 1 citation
The current state of regulatory affairs is mapped and ways of moving from the existing legislation on genetic engineering to an informed discussion about the future of this technology are entertained, highlighting several important aspects of the new generation of molecular tools for precision genetic engineering.
M. Valverde, V. de Lorenzo· International Microbiology· 1 citation
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