Author

V. Döring

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Open access Oct 2026

Population diversity and accelerated mutation drive anaerobic bacterial adaptation during long-term solvent stress

ABSTRACT Experimental evolution can uncover general mechanisms by which microorganisms adapt to environmental stress. Here, we investigate evolutionary trajectories of the anaerobic, lignocellulose-fermenting bacterium Lachnoclostridium phytofermentans ISDg (family Lachnospiraceae) during >2,000 generations of automate...

Tom Zaplana, Magali Boutard, Ivan Dubois et al. · mSystems · 0 citations

Jul 2026

Metabolic adaptation enabling D-xylose assimilation via the Entner-Doudoroff pathway in glycolysis-impaired Escherichia coli strains.

This study revealed that mutations in key enzymes and transcriptional regulators at various metabolic branching points were essential for effective growth on D-xylose, enabling optimized partitioning of carbon through central metabolism despite the loss of the canonical EMP glycolytic route.

C. Iacometti, Valérie A. Delmas, Mélodie Cadillon et al. · Metabolic Engineering · 0 citations