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V. Dushenkov

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Review Open access Sep 2026

FROM PLANT DEFENSE TO HUMAN THERAPEUTICS: MULTI-TARGET CHEMISTRY AND AI-GUIDED DISCOVERY OF RESISTANCE-RETARDING ANTIBACTERIALS

Antimicrobial resistance (AMR) is a major threat to modern medicine, driven largely by the widespread use of single-target antibiotics that create strong, narrow selective pressures and can be overcome by a single genetic change in the pathogen. This conceptual review argues that plants, which have been combating bacte...

V. Dushenkov, L. Glozman, A. Dushenkov · 0 citations
Open access Aug 2026

Antiviral Activity of the Polyene Macrolide Roseofungin Against Influenza a Virus: In Vitro, In Ovo, and Preliminary In Vivo Evaluation

Roseofungin, a polyene macrolide antibiotic produced by Streptomyces roseoflavus, was evaluated for antiviral activity against Influenza A virus using complementary in vitro, in ovo, and preliminary in vivo toxicity models, supported by molecular docking and molecular dynamics simulations. The compound exhibited antivi...

A. Bogoyavlenskiy, V. Berezin, P. Alexyuk et al. · 0 citations

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