Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
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Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
A multivariate blood-based framework integrating 19 molecular assays and six risk instruments in the Bio-Hermes-001 cohort supports resilience and resistance as molecularly distinct subgroups and provides a scalable framework for pathology-informed stratification and mechanistic investigation.
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