Brain single-photon emission computed tomography (SPECT) imaging using I-123 DaTSCAN is an effective tool for the diagnosis and follow-up of Parkinson disease. Reducing acquisition time decreases the likelihood of patient motion, improves patient comfort, and increases scanner throughput. However, shorter acquisition t...
Y. Salimi, Z. Mansouri, G. Mathoux et al.· Journal of imaging informati...· 0 citations
Findings support a 3-level interpretation of amyloid PET beyond binary classification and highlight the clinical relevance of the intermediate zone, which delineates biologically and clinically distinct stages along the amyloid continuum.
G. Mathoux, C. Boccalini, D. Peretti et al.· Journal of Nuclear Medicine· 0 citations
Generalized additive models examined clinical progression on the basis of visual and CenTauRz-based assessments of tau PET positivity and highlighted the need for new quantification approaches to better capture the complex patterns of tau deposition, important for early AD detection and monitoring.
Stamatia Karagianni, Alexis Moscoso, Sheelakumari Raghavan et al.· Journal of Nuclear Medicine· 0 citations
Ratios combining biomarkers of both amyloid and tau, such as Aβ42/pTau, consistently outperformed individual biomarkers in detecting amyloid and tau PET positivity and enhanced clinical utility by highlighting ambiguous cases requiring further assessment.
Sophie Mutel, F. Ribaldi, Augusto J. Mendes et al.· Alzheimer's Research & T...· 0 citations
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al.· Journal of the American Medi...· 5 citations
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