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Open access Aug 2026

Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis.

Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience. NPY (neuropeptide Y), a highly abundant brain neuropeptide, has emerged as an important regulator...

Giovanna Cazzolla, David Toppe, Gina Krause et al. · 0 citations
Open access Sep 2026

Site-resolved spatial and structural interactome of a human cell

The spatial and structural arrangement of proteins determine virtually every process in human cells. We combined gentle subcellular fractionation by differential ultracentrifugation with cross-linking mass spectrometry to systematically map this cellular proteome architecture with residue-level evidence, identifying 16...

Ze-Hong Zhang, Nanako Yokoyama, Ying Zhu et al. · 0 citations

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