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Author

V. Jairath

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4 papers indexed here

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Clinical trial Oct 2026

Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.

BACKGROUND Monoclonal antibodies targeting the interleukin-23 pathway are effective in treating inflammatory bowel disease. However, these therapies must be administered intravenously or by subcutaneous injection. METHODS We conducted a phase 2b, double-blind, randomized trial of oral icotrokinra, a peptide that bloc...

M. Abreu, B. Siegmund, L. Surace et al. · 0 citations
Review Open access Aug 2026

Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries

Despite considerable advancements in the therapeutic landscape of inflammatory bowel disease (IBD) for adults, long delays exist for paediatric IBD (pIBD) approval, with a median delay of >7 years following adult approval. Our aim is to summarise the landscape of pIBD clinical trials through a review of trial registrie...

D. Gupte, N. Suthar, John K. Macdonald et al. · 0 citations
Aug 2026

Cancer Risk with Advanced Therapies in Patients with Inflammatory Bowel Diseases: An Administrative Claims-based Study.

BACKGROUND AND AIMS We conducted a retrospective cohort study comparing the risk of cancer in patients with inflammatory bowel diseases (IBD) initiating advanced therapies (ATs). METHODS Using an administrative claims database (OptumLabs® Data Warehouse), we identified patients with IBD with no prior history of cance...

D. Ahuja, Kuan-Hung Yeh, Soo-kyung Park et al. · 0 citations
Review Open access Aug 2026

Targeting the TL1A pathway in inflammatory bowel disease: mechanistic insights and emerging therapeutic pipeline.

This narrative review provides a contemporary appraisal of TL1A-directed therapeutics in inflammatory bowel disease based on electronic searches through May 2026, and discusses therapeutic positioning and timing, the opportunity in acute severe UC, and the unusual standing of IBD as the lead indication for this mechani...

M. N. Quraishi, V. Jairath, B. Al-Bawardy · 0 citations

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