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Author

V. Jha

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Open access Aug 2026

Structural and mechanistic analysis of semisynthetic α-mangostin derivatives with anticancer activity via topoisomerase II inhibition.

Eleven novel alkyl/arylalkyl substituted α-mangostin derivatives (M2-M12) were synthesized from isolated α-mangostin (M1) from the pericarp of Garcinia mangostana L. extract. Among all the compounds, M10 exhibited the most potent antiproliferative activity against MCF-7 cells, with an IC₅₀ of 8.39 ± 0.07 μM, comparable...

M. K. Katiyar, Faheem Ahmed, Sonali Priyadarshini et al. · 0 citations
Open access Aug 2026

Targeting Insulin Signaling and TRAF2/JNK Pathway: A Comprehensive In Silico Study of Uncaria tomentosa Compounds

Investigation of mechanisms of action of 14 compounds from Uncaria tomentosa, a medicinal plant from the Amazon rainforest, using in silico modeling suggests that specific UT compounds may be used in experimental tests to investigate their therapeutic potential in managing T2D by modulating signaling pathways related t...

Bruna Freitas Marchi, Shraddha Parate, V. Jha et al. · 0 citations

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