Survivin mRNA-lipid nanoparticles promote activation of CD8+Granzyme B+ T cells and effector memory formation for effective oral cancer immunotherapy.
Effective cancer immunotherapy requires an understanding of the tumor microenvironment (TME) to overcome immune suppression and provide a durable anti-tumor response. Here, we present preclinical evaluation of survivin antigen-encoded mRNA lipid nanoparticles (mRNA-LNPs) in a murine oral cancer model. In vivo anti-tumo...