Author

V. Marcel

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Open access Oct 2026

A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells

A pipeline to identify translation-associated single-nucleotide polymorphisms (tranSNPs) by integrating analysis of total and polysome-associated mRNAs is developed and extensively validate, revealing an association between rs1053639 genotype and clinical outcome in colorectal cancer.

M. Hamadou, Laura Alunno, Tecla Venturelli et al. · iScience · 1 citation

Open access Sep 2026

MiR-662 impairs C/D box snoRNA expression and rRNA 2′-O-ribose methylation marks

Interestingly, a drastic decrease in SNORD levels (but not of their host genes) and a global decrease in rRNA 2’Ome was observed upon miR-662 overexpression, suggesting the involvement of miRNAs in snoRNA-induced modulation in rRNA epitranscriptomic marks might be a novel mechanism of fine regulation of the ribosome co...

Charlotte Filossi, Caroline Isaac, Mariam Jaafar et al. · BJC Reports · 0 citations

Open access Aug 2026

Loss of SNORD104-guided rRNA methylation promotes early adaptation to crizotinib in lung adenocarcinoma

Findings support a role for snoRNA-guided rRNA modification as a novel non-genomic mechanism in early adaptive responses to crizotinib therapy in LUAD.

Nour-El-Houda Mourksi, Caroline Isaac, J. Ripoll et al. · Cell Death & Disease · 0 citations