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Open access Aug 2026

Oligodendrocyte dysfunction in human age-related cognitive decline.

Cognitive decline in aging impacts quality of life, for which therapeutic interventions are lacking. Why some individuals experience more severe cognitive decline with aging is unclear. Here we uncover a role for the brain's myelin-forming cells-oligodendrocytes-in explaining this variance. By investigating neuropathol...

Georgina A. Craig, Emeric Merour, L. Seeker et al. · 0 citations
Review Open access Sep 2026

Oligodendrocytes in central nervous system health and disease.

Oligodendrocytes are a specialized class of glial cells responsible for myelination, which sustains central nervous system (CNS) function. Though long considered a passive and static cell, the oligodendrocyte is now recognized to actively support axonal energy demands through metabolic provision, modify neural signalin...

L. Ryan, V. Miron · 0 citations

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