Open access
Sep 2026
Identification of the Acetamide-Chalcone Derivative That Selectively Inhibits ABCG2 Transport Activity
Multidrug resistance (MDR) remains a major obstacle to effective cancer chemotherapy, often driven by the overexpression of ABC transporters such as ABCG2. In this study, we identified the synthetic chalcone derivative, B5, as a selective ABCG2 inhibitor. Among the 20 chalcone analogs evaluated, B5, bearing an acetamid...
Arthur Henrique Gomes de Oliveira, E. Ducas, Thales Kronenberger et al.
· ACS Omega · 0 citations