Hippocampal Cc2d1a/Freud-1 Knockdown Alters Serotonin and Dopamine Systems and Depressive-Like Behavior in ASC (Antidepressants Sensitive Catalepsy) Male Mice.
Brain monoamine systems regulate a wide spectrum of behaviors. Serotonin (5-HT) is traditionally linked to depression, whereas dopamine (DA) is associated with anhedonia and impaired motivation. The genes for the 5-HT1A receptor (Htr1a) and DRD2 receptor (Drd2) share a common transcription factor, Freud-1, encoded by C...