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Author

V. Ntranos

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Open access Sep 2026

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate

Regulatory T (Treg) cells in mice can lose lineage identity and acquire proinflammatory functions, but whether human Treg cells are similarly susceptible to cytokine-driven destabilization remains unclear. Here we established an in vitro model of human Treg cell destabilization defined by silencing of the lineage-speci...

Patrick Ho, Alexander Vu, Joey C. Leung et al. · 1 citation
Open access Jul 2026

PepCL: A replay-based continual learning framework for updating peptide-MHC models

PepCL (Peptide-MHC Continual Learning), a continual learning framework for updating peptide-MHC predictors with new assay data while explicitly preserving prior MS knowledge, is introduced and it is demonstrated that PepCL allows MHCPrime to learn previously unseen, assay-specific information while preventing catastrop...

P. Chati, Vishal D. Lashkari, Ankit Salhotra et al. · 0 citations

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