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Author

V. Ong

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Open access Sep 2026

Transcriptomic characterization of transitional B cells reveals four subsets with perturbed activation profiles in scleroderma

Summary We previously demonstrated that patients with scleroderma or systemic sclerosis (SSc) have elevated autoreactive transitional B cells, including against topoisomerase I (anti-topoisomerase I autoantibody [ATA+]). This suggests that defective transitional B cell tolerance could drive autoimmunity in SSc. To inve...

Claire F. Beesley, Nina R. Goldman, Gisela Gabernet et al. · 0 citations

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