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Open access Aug 2026

Pragmatic vs. naive genetic instrument selection in Mendelian randomization studies: a practical guide

Mendelian randomization (MR) is widely used to infer causal relationships using genetic variants as instrumental variables, yet the selection of genetic instruments is not always given sufficient attention. Many MR studies rely on default linkage disequilibrium (LD) clumping parameters (r2 <0.001, 10,000 kb), as implem...

A. C. Mason, G. Ballabio, V. Paz et al. · 0 citations

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