Author

V. Pelicic

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Open access Sep 2026

A short C-terminal plug motif in a conserved type 4 pilus component controls pilus-tip localisation and filament biogenesis

It is shown that the last 12 residues of PilC, representing ∼1% of the protein, are both necessary and sufficient for pilus-tip localisation and filament biogenesis, defining the molecular basis of PilC/PilY1 function and localisation, and establishing a broadly applicable model for T4aP biogenesis.

Milica Denic, Morgane Wuckelt, V. Roig-Zamboni et al. · bioRxiv · 0 citations