Impact of Renal Replacement Therapy on Severe Lactic Acidosis in Intensive Care Unit Patients: A MIMIC-IV Retrospective Replication Analysis
Abstract Introduction Severe lactic acidosis (SLA), defined as lactate ≥5 mmol/L, is a critical condition in intensive care unit (ICU) patients and is associated with high mortality. Despite the broad use of renal replacement therapy (RRT) to manage metabolic derangements, its impact on outcomes in SLA remains uncertai...