Open access
Oct 2026
Brain region- and solubility-dependent proteomic signatures of neurofibrillary tangle pathology in Alzheimer's disease
Neurofibrillary tangles (NFTs) are a hallmark of Alzheimer's disease. However, the molecular basis underlying their spatial heterogeneity and biochemical complexity remain unclear. To address this, we performed mass spectrometry-based proteomic profiling of two neocortical regions with different susceptibilities to NFT...
X. Zeng, E. Abrahamson, W. G. Balogun et al.
· medRxiv · 0 citations