Polygenic indices (PGIs) offer a tool for estimating genetic predispositions to personality traits such as neuroticism. Using genetic, survey, and registry-linked data from six Finnish cohorts (1992–2017;
N
= 20,121; ages 25–64), we examined how the Neuroticism Polygenic Index (NPGI) relates to a sequence of econom...
A. Hazak, J. Liuhanen, K. Kantojärvi et al.· European Journal of Personal...· 2 citations
Summary This study investigated the relationship between the gut microbiota and two obesity indicators, body mass index (BMI) and waist-hip ratio (WHR) in a well-phenotyped random population sample of 5846 participants. Associations were tested using multivariable-adjusted linear models and validated for BMI in an exte...
L. Yeo, J. Palmu, A. Havulinna et al.· iScience· 1 citation
The gut microbiome has been linked to cancer in many cross-sectional studies. These studies compared individuals with and without cancer, but they do not establish causation. Prospective cohort studies, with faecal samples collected before a cancer diagnosis, will be instrumental in assessing the role of the gut microb...
E. Vogtmann, Caroline Y. Um, S. Zouiouich et al.· The Lancet Microbe· 0 citations
PURPOSE
This study examines how genetic liability for Attention-Deficit/Hyperactivity Disorder (ADHD), measured using a polygenic index (ADHD-PGI), relates to both objective and subjective socio-economic outcomes in the general population.
METHODS
We studied six Finnish population-based cohorts (1992-2017; N = 20,121...
A. Hazak, J. Liuhanen, K. Kantojärvi et al.· Social Psychiatry and Psychi...· 0 citations
BACKGROUND
Stratification of stroke risk remains challenging, but metabolomic profiling offers the potential to detect new biomarkers and to improve early risk assessment of incident stroke. The objective of this study was to evaluate the association between circulating metabolites and the incidence of stroke in a case...
C. Schulte, Francisco M. Ojeda, Märit Jensen et al.· Stroke· 0 citations
It is demonstrated that robust signatures of co-abundant species can be prospectively associated with mortality, diabetes, liver disease, and sepsis risk among Finnish adults in the FINRISK population cohort based on a 20-year follow-up.
Himmi Lindgren, Chandler Ross, M. Ruuskanen et al.· Bioinformatics· 0 citations
Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.
Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al.· Molecular Systems Biology· 1 citation
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