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Author

V. Seplyarskiy

h-index 18 View on Semantic Scholar

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Sep 2026

Mutation rate heterogeneity biases variant effect prediction and reveals genuine mutational robustness.

The findings show that mutation rate heterogeneity systematically biases current variant effect prediction frameworks, highlight the need to model mutation probabilities explicitly in future VEPs, and reveal a genuine biological signal of mutational robustness.

Hossameldin Loay, Prathitha Kar, Evan Koch et al. · 0 citations
Open access Sep 2026

Extrachromosomal Circular DNA Function as Mobile Elements to Alter the Mammalian Germline Genome

The extrachromosomal circular DNA (eccDNA) in the mouse and human male germline represents a new mechanism in altering the mammalian germline genome and new insights are provided into how the mammalian germline genome can be altered.

Xin Zhang, Melanie Evans, S. Rajachandran et al. · 0 citations

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