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[This corrects the article DOI: 10.1016/j.eclinm.2026.104187.].
It is suggested that phytochemicals act as multi-target compounds rather than single cytotoxic agents with promising potential in combination therapies for colorectal cancer.
The renin-angiotensin system (RAS), traditionally recognized for cardiovascular and renal regulation, has emerged as a critical mechanistic player in neuropsychiatric pathophysiology. The brain possesses its own independent RAS with components located throughout limbic regions, cortical areas, and monoaminergic circuit...
Circadian and behavioural timing exposures showed trends associated with MASLD-related outcomes, with the most consistent evidence for shift work, and evidence for objective rest-activity rhythms, light exposure, meal timing, and melatonin phase remained limited or heterogeneous.
Preclinical data support the notion that modulation of AQPs activity may offer neuroprotection through restoration of homeostasis and reduction of inflammation in neurodegenerative disease, and its potential and limitations as a therapeutic target for the prevention of CNS disorders are described.
RIOK3 is identified as a promising therapeutic target for PDAC, with Venetoclax, Conivaptan, Drospirenone, and Irinotecan as repurposable candidates for further research.
A benzothiadiazole derivative is presented as a promising SERT‐modulating lead for AD, establishing a robust computational foundation for experimental validation and establishing a robust computational foundation for experimental validation.
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