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Author

V. Thallas-Bonke

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Open access Jul 2026

Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondrial dysfunction in diabetes

This study provides the first direct tissue-level functional evidence that mitochondrial metabolism is reprogrammed in the human kidney in diabetes before measurable kidney dysfunction develops, and defines an early bioenergetic signature characterised by tissue hypermetabolism despite impaired mitochondria-specific re...

C. Granata, A. Laskowski, V. Thallas-Bonke et al. · 0 citations

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