Mechanistic Insights, Structure-activity Relationships, and Safety Profile of Mitragyna speciosa Alkaloids
Mitragyna speciosa, better known as kratom, is a traditional medicinal plant from Southeast Asia. It contains mainly two indole alkaloids, mitragynine and 7- hydroxymitragynine, which differ from classical opioids by displaying a unique mode of opioid pharmacology. This review discusses the chemistry, Structure-Act...