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Open access Sep 2025

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro-derived neuromesodermal progenitors

Neuromesodermal progenitors (NMPs) produce the spinal cord and musculoskeleton in the elongating anterior-posterior axis. In vivo, NMPs possess dual potency, coinciding with regions coexpressing SOX2 and Brachyury (TBXT). In vitro, SOX2/TBXT co-expressing cells can be produced from pluripotent cells and, like their in...

A. Binagui-Casas, Anna Granés, A. Ceccarelli et al. · 1 citation

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