Author

VA Million Veteran Program

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Open access Aug 2026

Global genomics in over 4 million individuals prioritizes therapeutic targets for heart failure and its subtypes

The primordial role of metabolic pathways and adipokines as therapeutic targets for HF management is highlighted, and six cardiomyopathy genes were novel for HF and associated with cardiac structure and function.

D. Rasooly, G. Peloso, C. Giambartolomei et al. · medRxiv · 0 citations

Open access Aug 2026

Leukocyte DNA methylation-based signatures for atherosclerotic cardiovascular disease risk prediction in the Million Veteran Program

DNA methylation-based signatures were associated with incident ASCVD and modestly improved risk prediction beyond that of traditional risk factors, and an agnostic probe reliability-based approach was developed.

A. Barad, D. Khodasevich, P. F. Kho et al. · medRxiv · 0 citations