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Author

Václav Brázda

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Open access Sep 2026

Precise pH-triggered cleavage of PEG-lipid conjugates drives endosomal escape of siRNA from fusogenic lipid-based nanoparticles.

Novel pH-triggered RNA-LNPs (ZK2 LNPs) that comprise PEG-lipid oxime conjugates (5 mol%), prepared in situ using pH-reversible aminoxy-aldehyde click chemistry represent a powerful next generation LNP technology and demonstrate excellent LNP tolerability in vivo.

Zdeněk Kratochvíl, Dattary Shivajirao Bhosale, Melanie Schürz et al. · 0 citations
Open access Jul 2026

G‑quadruplexes as regulatory platforms for human transcription factors: insights from ChIP-seq data

The results indicate that G-quadruplex-prone sequences represent a common genomic feature associated with a number of human transcription factors and chromatin-associated regulatory proteins and support a model in which G4-rich regions act as selective regulatory scaffolds shaping transcription factor occupancy and gen...

Karolína Drápalová, Michaela Dobrovolná, Filip Kledus et al. · 0 citations

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