Moving beyond spike detection: High frequency-driven masking improves seizure onset zone localization in intracranial electroencephalography.
OBJECTIVE Interictal epileptiform spikes (IESs) are widely used biomarkers of epileptogenic tissue in presurgical epilepsy evaluation. However, their reliability for seizure onset zone (SOZ) localization in high-density intracranial electroencephalography (iEEG) remains inconsistent. It is underexplored whether this va...