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Valeriy A. Yakovlev

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Review Open access Sep 2026

3D Genome Engineering Using CRISPR/dCas Systems

Current CRISPR/dCas-based approaches for engineering three-dimensional genome architecture are summarized, their mechanistic basis and applications are discussed, and emerging therapeutic opportunities and major technical challenges in the field are highlighted.

N. Mamaeva, Valeriy A. Yakovlev, Nikolay V. Kristovskiy et al. · 0 citations

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