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Vanessa E. Wall

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Open access Sep 2026

HRAS promotes mutant NRAS-driven transformation with codon and allele specificity.

Wild-type RAS family members determine the signaling and therapeutic response in cancers driven by mutant HRAS and KRAS because they activate alternate RAS effector pathways. Here, we found that the requirement for wild-type RAS to support mutant NRAS-driven transformation correlated with codon-specific differences in...

Hyun Lee, Jacob M. Hughes, Joseph P. LaMorte et al. · 0 citations

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