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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Varen Talwar

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Open access Oct 2026

HIF-1–mediated PPME1 expression promotes breast cancer progression via AKT activation and β-catenin recruitment

Hypoxia-inducible factor 1 (HIF-1) orchestrates the transcriptional regulation of thousands of genes involved in breast cancer (BC) progression. Here, we identified protein phosphatase 2A (PP2A) methylesterase 1 (PPME1) as a critical HIF-1 target gene that drives oncogenic signaling under hypoxic conditions. In BC cell...

Yajing Lyu, Varen Talwar, Yong-Kang Yang et al. · 0 citations

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