Review
Open access
Oct 2026
Orthopedic implant allergies: a review of current knowledge on metal hypersensitivity and prosthesis failure
Metal hypersensitivity is an increasingly recognized factor in orthopedic implant failure, particularly in patients undergoing total joint arthroplasty (TJA), and may contribute to persistent pain, aseptic loosening, or early revision. This review synthesizes current evidence on the underlying immune mechanisms of meta...
Veronica Viola, N. Marelli, Teofila Caplanusi et al.
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