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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

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Veronika Alberg

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Open access Nov 2026

Parent-metabolite PBPK model of methotrexate to inform pediatric extrapolation, transporter-mediated drug–drug interactions, and renal impairment

Methotrexate (MTX) is widely used in treating chronic inflammatory diseases and in chemotherapy for both adult and pediatric patients. Its pharmacokinetics are complex, as MTX is a substrate of multiple transporters. Particularly during high-dose chemotherapeutic use, it is associated with severe toxicities including r...

C. Dette, F. Marok, Veronika Alberg et al. · 0 citations

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