Author

Victoria M. Pratt

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Clinical trial Open access Oct 2026

PHOENIX: a study protocol for a pilot randomised controlled trial of pre-emptive pharmacogenomic panel testing in acute care settings with health economic evaluations

Abstract Introduction Pharmacogenomic (PGx) panel testing may reduce adverse drug reactions (ADRs), treatment failures and downstream healthcare use by aligning prescribing with germline genetic variation. The PREPARE trial reported an approximately 30% reduction in clinically relevant ADRs using a pre-emptive multigen...

S. Lip, P. T. Pepler, A. McConnachie et al. · BMJ Open · 0 citations

Review Open access Aug 2026

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

The work presented here includes the first designation of decreased function alleles for both TPMT and NUDT15, reflecting new clinical data that demonstrate partial loss of enzymatic activity and reduced dose tolerance.

Bailey M. Tibben, Maud Maillard, Victoria M. Pratt et al. · Clinical pharmacology and th... · 0 citations