Aug 2026
Deciphering Protein-Protein Interactions in Suspension Formulation of Neutral Protamine Hagedorn Insulin Using Hydrogen/Deuterium Exchange-Mass Spectrometry.
HDX mass spectrometry of the crystalline suspension state of insulin-protamine interactions revealed that the N-terminal residues B1-11 are critical for interactions, with residues LeuB6 and GlyB8 being predominantly involved in the binding.
Shenbaga Moorthy Balakrishnan, S. M, Srivatsa Koduru et al.
· Analytical Chemistry · 0 citations