Open access
Aug 2026
Mapping the TCR–Peptide-HLA Interface through Hydrogen–Deuterium Exchange Mass Spectrometry
It is demonstrated that conventional peptide-level hydrogen–deuterium exchange mass spectrometry (HDX-MS) workflows can identify productive TCR engagement with their cognate pHLAs and shows that TCRs that bind centrally within the pHLA groove have distinct uptake profiles compared with those adopting alternative orient...
Thomas Powell, Alice Colyer, Gemma Wildsmith et al.
· Analytical Chemistry · 0 citations